The Science Journal of the American Association for Respiratory Care

1995 OPEN FORUM Abstracts

NEURORESPIRATORY DRIVE, RESPIRATORY MUSCLES EFFORTS AND MECHANICS OF BREATHING IN PATIENTS BEFORE AND AFTER SPECIAL TRAINING OF RESPIRATORY MUSCLES

Anatoly P.Zilber, M.D., Ph.D, Elmira K.Chikhmirzaeva, M.D. Petrozavodsk University, Petrozavodsk, Russia

Pathogenesis and clinics of chronic respiratory failure always consist all three types of disorders - central neural regulation, respiratory muscles activity and respiratory mechanics, but only respiratory mechanics tests are used in routine clinical practice of respiratory medicine.

We studied 55 patients with chronic respiratory failure due to chronic obstructive pulmonary diseases (COPD) and 41 normals, using the original noninvasive method of simultaneous investigation of neurorespiratory drive (P_{100} and P_{100}/V), inspiratory and expiratory muscles efforts (P_{mus insp} and P_{mus exp}) as the mouth occlusion pressure during whole inspiration and expiration as well as respiratory mechanics (maximal expiratory flow-volume curve parameters, respiratory resistances and other tests). The method was worked out on the basis of lung computer by common principle and simultaneous procedure of occlusion pressure measurement. 18 patients were investigated during half a year special training program of respiratory muscles with using different artificial aerodynamic resistances. The consumption of oxygen by respiratory muscles was measured.

The results showed that after one month of training P_{mus insp} changed from 64,8±7,92 to 77,7±8,3 cm H_2O (M±m). In the same time P_{100} decreased from 5,94±0,52 to 3,61±0,58 cm H_2O, demonstrating an improvement of the neurorespiratory drive as the reflection of amelioration of inspiratory muscles strength and small airways conductivity. There is a quite good correlation between changes of all three functions - neurorespiratory drive, respiratory muscles efforts and respiratory mechanics.

The training during next 2 months improved all indices by 5-10%. Next 3 months of training (that is half a year) gives an insignificant improvement of all functions.

The measurement of oxygen consumption by respiratory muscles during the training provides to modulate the regime of training.

Thus the special training of respiratory muscles improved inspiratory and expiratory muscles efforts, decreased P_{100} and P_{100}/V and ameliorated small airways conductivity.

The method of simultaneous evaluation of 3 components of chronic respiratory failure is noninvasive, very informative and can be used with great success in functional investigation of COPD patients as well as in control of respiratory care effectivity.

OF-95-232

You are here: RCJournal.com » Past OPEN FORUM Abstracts » 1995 Abstracts » NEURORESPIRATORY DRIVE, RESPIRATORY MUSCLES EFFORTS AND MECHANICS OF BREATHING IN PATIENTS BEFORE AND AFTER SPECIAL TRAINING OF RESPIRATORY MUSCLES