The Science Journal of the American Association for Respiratory Care

1996 OPEN FORUM Abstracts

COMPARISON OF MDI ALBUTEROL DOSE DELIVERY IN A HEATED, HUMIDIFIED ADULT VENTILATOR CIRCUIT WITH THE MV-AEROCHAMBER AND ACE RESERVOIR SYSTEMS

Randy DeKler MS RRT, Joseph L Rau PhD RRT. Georgia State University, Atlanta GA

Introduction: No date exist to compare the dose delivery of the prototype MD spacer, MV-Aerochamber (Monaghan Medical Corp), and the ACE (Diemolding Healthcare Corp) Spacer device. Purpose: This study examined the dose delivery of MDI albuterol through an adult, heated, humidified ventilator circuit using the MV-Aerochamber and ACE spacer devices. Methods: Albuterol sulfate (Proventil, Schering) was delivered using 6 samples each of the MV-Aerochamber and ACE spacer devices. An MA-1 ventilator set to deliver a V_{T} of 800 mL, of 10/min, and flowrate of 60 L/min. Ventilation was delivered to a Manley test lung (Ohmeda Corp) set on C_{L} 50, R_{AW} 0 through a size 8.0 endotracheal tube (ETT). A servo-controlled Fisher- Paykel heated humidifier (model MR-480) was used to provide approximate saturation of inspired gas between 30-35ÂșC. Each test dose measurement used 5 MDI actuations, and each actuation was spaced 5 breaths apart. Cotton filter material placed at the distal end of the ETT collected the aerosolized drug. The filter was then washed in a glass vial containing 20 mL of ethanol. Spectrophotometric assay at a wavelength of 278 nm was used to measure each sample solution. Statistical analysis was then applied to the collected data. Results:

MV-Aerochamber ACE

Unit# Dose (mcg) Dose (%) Dose(mcg) Dose(%)

1 37.6 41.7 41.0 45.5

2 47.0 52.2 42.3 47.0

3 39.5 43.8 30.9 34.3

4 43.2 48.0 35.2 39.1

5 31.8 35.3 44.4 49.3

6 36.9 40.9 39.0 43.3

Mean 39.3 43.7 38.8 43.1

SD 5.28 5.88 4.98 5.53

Conclusions: The MV-Aerochamber performed equally as well as the ACE under the outlined study methodology. There was no statistical difference (p=0.8728) detected in the measure of the 6 units tested for the 2 brands using a Mean Whitney U test.

Reference: OF-96-058

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