The Science Journal of the American Association for Respiratory Care

1997 OPEN FORUM Abstracts

INFLUENCE OF HE:OX ON AEROSOL DELIVERY FROM A MDI AND SPACER DURING MECHANICAL VENTILATION

J. Fink, MS, RRT, R.Dhand, MD, P.Fahey, MD, M J Tobin, MD Div of Pulm and Crit Care Med, Edward Hines Jr. VA Hospital and Loyola Univ Chicago, Stritch School of Medicine, Hines IL.

Helium: oxygen (He:O_{2}) mixtures have been employed as an adjunct to decrease airway resistance and to relieve respiratory distress experienced by patient with severe airway obstruction during mechanical ventilation. The effect of He:O_{2} on aerosol delivery to the lower respiratory tract with a MDI has not been well described. To that end, we compared aerosol delivery of albuterol from a MDI and spacer chamber during mechanical ventilation (CMV), while delivering He:O_{2} of 80:20 and air under both dry and heated/humidified (wet) conditions to a tracheobronchial model attached to a lung simulator. A monitor (VenTrak) was used to measure volumes and flows with both gas mixtures and albuterol deposition on filters distal to the tracheobronchi model was determined by spectrophotometry. Results (below) expressed as the % of nominal dose delivered.

(See original for figure)

Delivery of albuterol was greater with 80:20 He:O_{2} than air under both wet and dry conditions (p < 0.001). Drug delivery was reduced with heat and humidification with both gases (*p < 0.15). Conclusion: When a MDI and spacer chamber was employed, He:O_{2} improved drug delivery to the bronchi compared to air during CMV.

Veterans Administration Research Service

OF-97-176

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