The Science Journal of the American Association for Respiratory Care

1997 OPEN FORUM Abstracts

EVALUATION OF THE SENSORNOX NITRIC OXIDE/NITROGEN DIOXIDE ANALYZER.

Nancy Craig RRT, Barry Grenier RRT, Peter Betit RRT. Respiratory Care Department, Children's Hospital, Boston, MA.

The measurement of nitric oxide (NO) and nitrogen dioxide (NO_{2}) concentrations is an important component of an inhaled NO delivery system. We evaluated the SensorNOx NO/NO_{2} monitor (SensorMedics Corp, Yorba Linda, CA). The monitor was calibrated according to the manufacturer's specifications. NO from an 800 ppm source tank was titrated into the inspiratory limb of a VIP Bird ventilator. The ventilator, attached to a test lung, was set in the IMV mode at a PiP/PEEP of 30/5 cmH_{2}O, rate of 30, and a Ti of 0.6 secs. Predicted NO concentrations were determined from the equation, [NO_{PRED}] = (NO_{SOURCE})(V[dot]_{NO})/(V[dot]_{NO} + V[dot]_{VENTILATOR}). All flow rates were verified and 7 [NO_{PRED}], range 2.5-80 ppm, were used. Following 5 minutes of stabilization, NO and NO_{2} measurements were recorded for each [NO_{PRED}] and at a set FDO_{2} of 0.3, 0.6 and 1.0. The study was repeated 5 times and [NO_{PRED}] was compared to measured NO. The bias ± precision between [NO_{PRED}] and measured NO was -0.26 ± -0.39 ppm (p=0.17). The mean % bias was -0.84% and the limits of agreement were -1.96 to 1.44 ppm. The bias at each FDO_{2} was -0.94 ppm at 0.30, -0.30 ppm at 0.60 and 0.45 ppm at 1.0. There was a significant difference in bias between FDO_{2} of 0.30 and 1.0 (p=0.003). The mean NO_{2} measurements were 0.03 to 1.72 ppm. This monitor provided accurate measurements of NO concentrations and is suitable for clinical use. The increase in bias as FDO_{2} is increased would not be significant in the clinical setting. We have found this monitor easy to use, and that the side-stream sample design provides the capability of measuring environmental NO and NO_{2} levels.

OF-97-109

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