The Science Journal of the American Association for Respiratory Care

1997 OPEN FORUM Abstracts

A NOVEL BREATH-ACTUATED SMALL VOLUME NEBULIZER UNDER SIMULATED ADULT USE CONDITIONS

R. Blacker, J.P. Mitchell, M.W. Nagel and A.M.W. Verdun, Trudell Medical, London, Canada.

Pneumatic small volume nebulizers (SVNs) in which atomization only occurs during the inhalation phase of the breathing cycle has important ramifications in terms of the efficiency of medication delivery. We report an investigation in which the effectiveness for the delivery of salbutamol (Ventolin(r) nebules: 5 mg/2.5 ml, Glaxo Wellcome, Canada) via a prototype breath-actuated SVN (Trudell Medical, Canada (TRU) was compared with that of a high performance closed-system SVN (Ventstream^{TM}, Medic-Aid, Pagham, U.K. (VEN)). Each nebulizer was connected in turn to a dual-chambered test lung with one chamber driven by a ventilator and the other connected to the SVN mouthpiece. Aerosolized salbutamol delivered on inhalation (800 ml tidal volume, I/E of 1/1, 15 breaths/min) was collected on a filter (Filtrete^{TM}, 3M Corp., St Paul, MN) located at the mouthpiece. Oxygen (440 kPa, 8 l/min) was used to operate each SVN, and the contents of a single nebule (2.5 ml) were added to the reservoir at the start of each test. Over a 5 minute period of use, the TRU SVN provided 1.74 ± 0.04 mg salbutamol to the filter (n=5 replicates), significantly more than the VEN which delivered 1.28 ± 0.01 mg in 3.5 min (Mann Whitney Rank Sum Test, p = 0.008), after which the device sputtered dry (n = 5 replicates). These data indicate that the new breath-actuated device may have important benefits in reducing wastage of medication by operating more efficiently, as well as reducing exposure to the care-giver.

OF-97-028

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