The Science Journal of the American Association for Respiratory Care

1998 OPEN FORUM Abstracts

COMPARATIVE ASSESSMENT OF A SMALL VOLUME VALVED HOLDING CHAMBER (VHC) WITH A SMALL VOLUME SPACER FOR THE DELIVERY OF FLUTICASONE PROPIONATE

J.P. Mitchell, M.W. Nagel and A. Archer. Trudell Medical International, London, Canada.

Fluticasone propionate (FP) is becoming widely prescribed as a corticosteroid for the treatment of asthma. This study compared the performance of 5 VHCs (AeroChamber(r), Monaghan Medical Corp., Plattsburgh, NY) with 5 spacers (MicroChamber^{TM}, Respiratory Delivery Systems Inc., Chelmsford, MA) with Flovent(r) (110 µg/dose FP, Glaxo Wellcome (Canada) Inc.) delivered by metered-dose inhaler (pMDI). Total and fine particle ( < 4.7 µm aerodynamic diameter) unit doses from each group of devices were measured using an Andersen cascade impactor (Graseby Andersen, Smyrna, GA) equipped with USP Induction Port to collect the aerosol delivered by the pMDI at a constant flow rate of 28.3 ± 0.5l/min. The mass of FP collecting in each of the impactor components was assayed by HPLC-UV spectrophotometry. Both fine particle (FD) and total (TD) unit doses from the AeroChamber(r) VHCs (56.0 ± 0.8 µg (FD); 60.9 ± 0.8 µg (TD)) significantly exceed that delivered by the MicroChamber^{TM} spacers (38.2 ± 6.5 µg (FD); 44.0 ± 3.6 µg (TD)) (paired t-test, p < 0.001). The mass fraction of the aerosol contained in fine particles (91.9 ± 0.3% (AeroChamber(r)); 86.1 ± 8.7% (MicroChamber^{TM})) were comparable (p = 0.15). The larger volume of the AeroChamber(r) VHC (135 ml) appears to have both improved the output of FP delivered in comparison with the MicroChamber^{TM} spacer (100 ml), and at the same time maintained a high proportion of the dose as therapeutically useful fine particles. The inter-device variability for the group of spacers was noticeably greater than that observed with the VHCs, suggesting that an inhalation valve may improve uniformity of dose delivery.

The 44th International Respiratory Congress Abstracts-On-Disk®, November 7 - 10, 1998, Atlanta, Georgia.

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