The Science Journal of the American Association for Respiratory Care

1998 OPEN FORUM Abstracts

PARTICLE SIZE AND OUTPUT COMPARISON OF THE BREATHRITE AND AEROCHAMBER AEROSOL HOLDING CHAMBERS.

R.J. Perry B.S., W. Chiang and J.S. Ilowite M.D. SUNY at Stony Brook, NY 11794, California Measurements, CA 91024 and Winthrop-University Hospital, Mineola, NY 11501.

The Breathrite (Ventlab Corp.) is a new aerosol holding chamber (HC), which has the advantage of collapsibility and increased portability, potentially improving compliance among patients that benefit from holding chambers but are reluctant to carry bulky devices outside their home. Prior to clinical use, new HC design characteristics are bench tested. Therefore we measured the aerosol particle size and output efficiency of the Breathrite (BR) and also of the FDA approved Aerochamber(r) (AC) for comparison. Both devices were combined with beclomethasone (D#1), albuterol (D#2) or cromlyn (D#3) MDIs and tested in triplicate using previously published techniques (Kim, C.S. et al., ARRD 1985; 132:137-142 & 1987; 135:157-164) of cascade impaction (for particle sizing) and filter sampling (for output efficiency). Cascade data was analyzed via log probability plot to determine the mass median aerodynamic diameter (MMAD) in microns (µm) and efficiency data was calculated as the aerosol mass produced from each HC divided by the MDI dose per puff and expressed as a percent. Results are summarized in the following table.

Device D#1 D#2 D#3

MMAD (µm)±SD

BR 0.99 ± .07 1.62 ± .03 2.59 ± .09

AC 0.95 ± .06 1.62 ± .09 2.40 ± .09

Efficiency (%)±SD

BR 74.6 ± 7.3 61.5 ± 4.6 53.5 ± 3.2

AC 48.4 ± 3.6 47.4 ± 1.3 37.5 ± 8.3

For the three drugs tested, our analysis demonstrated a 42% greater efficiency of the Breathrite over the Aerochamber with nearly identical aerosol particle sizes. We believe that patients should have similar drug aerosol deposition patterns in the lung with either HC and a significantly higher inhaled drug dose via the Breathrite. The clinical relevance of these data remains to be determined, however.

The 44th International Respiratory Congress Abstracts-On-Disk®, November 7 - 10, 1998, Atlanta, Georgia.

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