The Science Journal of the American Association for Respiratory Care

1999 OPEN FORUM Abstracts

OFF LINE EXHALED NITRIC OXIDE LEVELS AS A MARKER IN LUNG DISEASE.

Daniel, Laskowski R.P.F.T. SC Erzurum MD, RA Dweik MD. Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195

Exhaled Nitric oxide (ENO) has been proposed as a noninvasive marker for lung disease. Currently there are two methods of measurement of ENO, (1) online direct-measurement as the patient exhales into the analyzer. (2) offline measurement of NO in exhaled gases collected in a reservoir bag. Offline measures are useful in that sampling can be performed at remote sites and stored for later measurement. We investigated the offline measurement from two Emergency Departments, one within our institution and the other a local Trauma center. Emergency room Personnel were trained in the procedure. We evaluated the data for reproducibility

Exhaled gases were collected into mylar balloons. The patient inhaled room air to total lung capacity then exhaled through a mouthpiece with 10 cm of PEEP as resistance to reduce nasal gas contribution to the sample, a known source of contamination. Two exhaled breaths were collected in mylar balloons with no breath hold, and two exhaled breaths were collected with a 15 second breath hold.

TABLE 1
GROUP n CORR P VALUE MEAN ±SE
BH #1 31 0.935 <0.001 25 ± 3
BH #2 25 0.935 <0.001 27 ± 4
NO BH#1 31 0.758 <0.001 24 ± 3
NO BH#2 24 0.758 <0.001 22 ± 2

Table one is the statistical results of 31 patients sampled. There was no significant statistical difference between the two sets of samples with and without breath hold. ENO can be measured offline using a mylar balloon collection technique with accuracy and reproducibility. This method may find future value as a marker for pulmonary disease.

OF-99-226

You are here: RCJournal.com » Past OPEN FORUM Abstracts » 1999 Abstracts » OFF LINE EXHALED NITRIC OXIDE LEVELS AS A MARKER IN LUNG DISEASE.