2001 OPEN FORUM Abstracts
Analysisof Clinical Characteristics and Drug Sensitivity Tests of Lower RespiratoryTract Infection by Xanthomonas Maltophilia
Wenxuan Cao, Liu LiDepartment of Pharmacology, Tianjin Bailou Hospital, Tianjin China 300040 WeiminWang Department of Respiratory, Tianjin Red Cross Hospital, Tianjin China 300211
Objective toanalyze the clinical characteristics of lower respiratory tract infection causedby Xanthomonas maltophilia and to investigate the antibiotic sensitivityof Xanthomonas maltophilia strains.
Methods Retrospectivestudy of the clinical data of 54 cases with lower respiratory tract infectionby Xanthomonas maltophilia, including risk factors of morbidity, clinicalsymptoms and signs, x-ray findings, blood routine test, treatment and prognosis.Drug sensitivity against strains of Xanthomonas maltophilia by K-B methodwas studied.
Results Therewere 39 males and 15 females, the mean age being 51±17 years. 87% of the caseshad underlying diseases, most of which were COPD complicated by respiratoryfailure. 57% of the cases were immunocompromised. 39% of the cases were in ICUof CCU. 54% of the cases accepted invasive treatments, and 93% of the caseswere given broad-spectrum antibiotics. Clinical manifestations include chill(72%), fever (80%), cough (94%) and expectoration (91%). The chest x-ray revealedinfiltration in lower lobes of both lungs. 16 cases had consolidations, and11 cases were complicated with pleural effusions. The drug sensitivity testin vitro showed that these strains were multiresistant to commonly used antibiotics,and drugs whose sensitive rate were over 50% included SMZco, ceftazidine, andtimentin.
ConclusionsThe lower respiratory tract infections caused by Xanthomonas maltophiliadevelop in patients with various underlying diseases, especially in the immunocompromisedpatients. Risk factors of morbidity were; patients in ICU of CCU, acceptanceof invasive treatment and, inappropriate use of broad-spectrum antibiotics.Clinical manifestations include severely toxic symptoms and some cases had pulmonaryconsolidations and pleural effusion.