2001 OPEN FORUM Abstracts
Changes of Eosinophil Cationic Proteinand Soluble Interleukin-2 Receptor in Bronchial Asthma.
Jing Xu, jian Wang, Jiangping ZhangDepartment of Internal Respiratory, Tianjin Bailou Hospital, Tianjin China 300040
Objective In this study ,an attempt was made to clarify the roles played by eosinophil cationic protein(ECP) and soluble interleukin-2 receptor (sIL-2R) in the pathogenic mechanismof asthma.
Methods The fluorescent enzymeimmunoassay (FEIA) and BA-ELISA were adopted to determine ECP and sIL-2R insera from 30 healthy subjects, 61 patients with advanced bronchial asthma. ECPand sIL-2R in sera from 37 patients were determined continuously after treatment.Results The results showed that both the levels of ECP and sIL-2R in sera fromthe patients with bronchial asthma in the acute stage were significantly higherthan those from the controls (P<0.01). Both the levels decreased significantlyafter treatment (P<0.01).
Conclusion ECP is an importantinflammatory medium for airway inflammation, and the level of ECP in serum isconductive to the judgment for the activity and the severity of asthmatic airwayinflammation. The results indicated that a significant correlation exists betweenthe activation of eosinophil and that of T-lymphocyte, as well as between theincreased level of ECP and the activation of T-lymphocyte.