2002 OPEN FORUM Abstracts
Changes of Eosinophil Cationic Protein and Soluble Interleukin-2 Receptor in Bronchial Asthma
1. Yujing Wang; 2. Jing Xu
of Hospital Management, Tianjin Medical University, Tianjin 300070, CHINA
2. Dept. of Respiratory Diseases, Tianjin Bailou Hospital, Tianjin 300040, CHINA
Objective: In this study, an attempt was made to clarify theroles played by eosinophil cationoc protein (ECP) and soluble interleukin-2 receptor (sIL-2R) in the pathogenic mechanism of asthma.
Methods: The fluorescent enzyme immunoassay (FEIA) and BA-ELISA were adopted to determine ECP and sIL-2R in sera from 30 healthy subjects, 61 patients with advanced bronchial asthma. ECP and sIL-2R in sera from 37 patients were determined continuously after treatment.
Results: The results showed that both the levels of ECP and sIL-2R in sera from the patients with bronchial asthma in the acute stage were significantly higher than those from the controls (P<0.01). Both the levels decreased significantly after treatment (P<0.01).
Conclusion: ECP is an important inflammatory medium for airway inflammation, and the level of ECP in serum is conductive to the judgment for the activity and the severity Of asthmatic airway inflammation. The results indicated that a significant correlation exists between the activation of eosinophil and that of T-lymphocyte, as well as between the increased level of ECP and the activation of T-lymphocyte.