2005 OPEN FORUM Abstracts
AN IN VITRO INVESTIGATION OF NEBULIZED ALBUTEROL DELIVERY BY PEDIATRIC AEROSOL FACEMASKS TO SPONTANEOUSLY BREATHING INFANTS
Hui-Ling Lin MS RRT, Ruben D Restrepo MD RRT, Douglas S Gardenshire MS RRT, Joseph L Rau PhD RRT FAARC. Cardiopulmonary Care Sciences Department. Georgia State University. Atlanta, GA
Background: Both aerosol facemask design and the distance at which is placed from the faceaffect availability of nebulized medications to pediatric patients.
Purpose: To evaluate in vitro the inhaled drug mass delivery with three types of pediatric aerosol masks at three different distances from the face using a model of a spontaneously breathing infant.
Methods: We compared a standard pediatric aerosol mask (SAM) and two proprietary pediatric aerosol masks (the DragonTM (DAM) and the FishTM (FAM)) attached to a Misty-Neb nebulizer. Aerosol delivery with each type of mask was measured at 0 cm (mask directly applied to the face), 1 cm, and 2 cm away from a mannequin face. Each nebulizer was filled with a 3 mL unit dose of albuterol sulfate and powered by oxygen at 8 L/min for a total of 5 minutes of nebulization. The nebulizer was connected to the Active Servo Lung 5000 (IngMar Medical Pittsburgh, PA) to simulate a spontaneously breathing infant. We measured (1) inhaled mass by collecting the nebulized drug in a two-way anesthesia filter at the breathing simulator inlet, (2) residual drug lost in the nebulizer by weighing each nebulizer empty, after filling, and after nebulization, and (3) estimated drug lost to atmosphere by subtracting the measured inhaled amount and nebulizer residual amount from the nominal dose.
Results: There was a significant difference in the inhaled drug mass between traditional mask, the Dragon mask, and the Fish mask. Furthermore, there was a significant difference between 0 cm and 2 cm with all configurations.
CONCLUSION: The Fish mask provides statistically significant higher inhaled mass compared to a standard pediatric aerosol mask and the DragonT aerosol mask. A pediatric aerosol mask should be closely fit on patient's face to optimize drug delivery.