2007 OPEN FORUM Abstracts
A STUDY OF EXHALED NITRIC OXIDE IN PATIENTS WITH AIRWAY DISEASES
Y. Chang1, M. Lin1, G. Wan2
Epidemiological studies have showed that the prevalence rate of asthma increases rapidly in recent year. This study was designed to attempt to assess the relationships between air-pollutants and the severity of airway function in patients with asthma and chronic obstructive pulmonary disease (COPD) by using the fractional concentration of nitric oxide in exhaled breath (FeNO) and pulmonary function test (PFT).
We recruited 32 asthma patients, 31 COPD patients and 30 control cases from March 2005 to March 2006. Information was collected by questionnaire. A Chemiluminescenceâs analyzer was utilized to monitor FeNO and PFT was performed subsequently. Monthly mean concentrations of air pollutants from ambient monitoring site operated by Taiwan Environmental Protection Agency (EPA) which locate nearby subjectâs residence were also collected for comparison.
The concentration of FeNO in control group (14.73±9.50 ppb) was significant lower than asthma group (24.06±20.05 ppb) (p<0.05), but had no significant difference compared with patients with COPD. The FeNO in COPD correlated negatively with FEV1/FVC (r= â0.477, p<0.01), and correlated positively to the levels of SO2 (r= 0.454, p<0.01), NO2 (r= 0.384, p<0.05) and CO (r= 0.417, p<0.05).
Our results have shown that FeNO is a feasible method to use to monitor the airway function in patients with different airway diseases. Environmental air-pollutants may influence the FeNO in patients with airway diseases, especially in COPD patients. Hence, the measurement of FeNO is a practicable modality to evaluate the impact of different factors on respiratory function.