2007 OPEN FORUM Abstracts
COMPARISON OF FOUR NEBULIZERS FOR TREATMENT TIME AND DRUG DELIVERY
N. Tiffin1, J. May1, L. Weinstein2, J. Tiffin3
Respiratory Drug Delivery Rates (µg/min)
Background: Speed of nebulized drug delivery is important to optimize costs in acute care and maximize compliance to therapy in the home. This study’s objective is to measure and compare the speed of nebulized drug delivery in the respirable range and the treatment times of three common nebulizers and one new nebulizer.
Method: We measured drug delivery rate and treatment time of the new LC Sprint reusable nebulizer (Pari Respiratory Equipment), the LC Star reusable nebulizer (Pari), the Vixone (Westmed) and the 8900 (Salter Labs) nebulizers using cascade impaction. Fill volume was 3.0 mL for albuterol (salbutamol); 2.5 mL for ipratropium bromide and 2.0 mL for cromolyn sodium and sampling flow was 28 Lpm. Three tests of each nebulizer and each drug were performed. Treatments were considered complete after no visual aerosol was noted for more than 1 second. ANOVA with post hoc Fisher’s LSD was performed to determine statistically significant differences with an alpha value less than 0.05.
Results: Data is presented as mean [sd] for cromolyn sodium only. Figure shows treatment time in minutes and respiratory drug delivery rate in ug/min for the four tested nebulizers. Ipratropium and albuterol showed similar results. All results were statistically different at the p<0.01 level except albuterol RDDR at p<0.05.
Conclusion: The Pari LC Sprint provided a much shorter treatment time with greater medication delivered in the respirable range per minute than the other nebulizers tested. Clinicians can potentially save time and cost using the LC Sprint and not have to re-formulate or sacrifice drug delivered in the optimal particle size range for pulmonary deposition. Compliance to therapy may increase in the non-acute settings.
|LC Star||LC Sprint||Vixone||8900|
|albuterol||134 ||163 ||57 ||36 |
|ipratropium||33 ||42 ||14 ||36 |
|cromolyn sodium||1846 ||2043 ||590 ||339 |
Respiratory drug delivery rates (RDDR) for four tested nebulizers and three medications (mean [sd]). RDDR is a product of total output rate of the nebulizer and respiratory fraction of the aerosol.