The Science Journal of the American Association for Respiratory Care

2008 OPEN FORUM Abstracts

EVALUATION OF TWO VALVED HOLDING CHAMBERS WITH FACEMASK ATTACHMENTS FOR PEDIATRIC USE WITH A NEW SMALL CHILD FACE MODEL

Dominic P. Coppolo1, Jolyon P. Mitchell2, Heather A. Mackay2, Valentina I. Avvakoumova2, Mark W. Nagel2



Background: Valved Holding Chambers (VHCs) with facemask as patient interface are an important adjunct in delivery of medication particularly to infants and young children. Performance testing needs to be undertaken with the facemask in place to simulate clinical use.

Methods: We evaluated the effect of two different but similar-sized VHCs (AeroChamber Plus® and AeroChamber Z-Stat Plus®, Monaghan Medical Corp.) each with either a small or medium facemask on delivery of albuterol (2-actuations of Ventolin® HFA, GlaxoSmithKline) to an oral-breathing face model with surface texture that responded at locations where the mask was applied with a force of 1.6 kg. Both groups of VHCs were prepared in accordance with manufacturer instructions to minimize the influence of electrostatic charge. Flow rates of 4.9, 8.0 and 12.0 L/min were examined in combination with a delay time of 2 seconds. These conditions were considered to be representative of children 6-12 months, 2-5 years and > 5 years old. Aerosol was collected at the lips of the model and the emitted mass (EM) determined by HPLC-UV spectrophotometry.

Results: Values of EM (mean ± SD; μg/actuation) for each condition are summarized in the Table.

Conclusion: The performance of either VHC with the same facemask was broadly equivalent at each flow rate.