The Science Journal of the American Association for Respiratory Care

2008 OPEN FORUM Abstracts

ILOPROST IMPROVES THE CARDIAC HEMODYNAMIC PARAMETERS OF PULMONARY ARTERY HYPERTENSION IN OPEN HEART SURGERY

Charles Oribabor1, Felix Khusid2, Emma Fisher2, Naim Mansuroglu1, Leonard Lee1, Anthony Tortolani1



Introduction: Pulmonary hypertension has been shown to increase perioperative morbidity and mortality in cardiac surgery necessitating the use of selective pulmonary vasodilators. Inhaled Iloprost, a prostacyclin PGI2 analogue, was evaluated for its systemic and hemodynamic effects.

Methods: We prospectively studied 10 patients with elevated mPAP. Iloprost (40 g) was administered via ultrasonic nebulization with Servo-I ventilators postoperatively. MPAP, cardiac index (C.I), and wedge pressures (PAOP) were measured with a pulmonary artery catheter. Pulmonary and systemic vascular resistance (PVR SVR) was calculated.

Results: Iloprost reduced PVR by 220.72 dynes/sec x cm-5 with sample correlation of 0.024 and mPAP by 18 mmHg with 0.058 correlation, but did not affect SVR.

C.I improvement had correlation of 0.001

Conclusion: Iloprost resulted in statistically significant reductions in mPAP and PVR accompanied by improvement in C.I. Iloprost could be considered as an alternative to Nitric Oxide.