The Science Journal of the American Association for Respiratory Care

2009 OPEN FORUM Abstracts

AEROSOL DELIVERY THROUGH ADULT HIGH FLOW NASAL CANNULA: AN IN VITRO COMPARISON WITH HELIOX AND OXYGEN

Patricia A. Dailey1, Kyle Walsh1, James B. Fink2, Robert Harwood2, Arzu Ari2; 1Respiratory Care, Baystate Medical Center, Springfield, MA; 2Division of Respiratory Therapy, Georgia State University, Atlanta, GA

INTRODUCTION. Heliox has been shown to reduce turbulence and improve aerosol delivery in a range of clinical settings. Delivery of aerosol with high flow nasal cannula (HFNC) has been applied to adults with severe asthma. A previously described model (Blaysham JAMPDD 2008) was modified to compare inhaled mass of albuterol with heliox and oxygen. METHOD. A vibrating mesh nebulizer (Aeroneb Solo, Aerogen) was placed at the inlet of a HFNC (Fisher & Paykel) A small adult cannula (Optiflow) was placed distal to the heated wire circuit with prongs placed into loose orifices simulating nares with a T-shaped trap and absolute filter connected to a breathing simulator (Vt 500 ml, 12 bpm, I:E of 1:2) 2.5 mg of albuterol sulfate in 3 mL was nebulized with Heliox (80:20) and Oxygen at 10, 30 and 50 lpm (n=3). Drug was eluted from the filter and assayed with UV spectrophotometry (276 nm). RESULTS. At 50 and 30 lpm, inhaled mass of albuterol was greater (p<0.05) with heliox (6 and 14%) than O2 (3.5 and 11%, respectively), but not at 10 lpm (28% and 27%). Aerosol delivery was inversely related to flow with both heliox and O2. CONCLUSIONS. Heliox increased aerosol delivery via HFNC up to 71%. Decreasing flow increased aerosol delivery via HFNC in this model. Sponsored Research - None

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