2010 OPEN FORUM Abstracts
INFLUENCE OF PEDIATRIC MASKS WITH A BREATH ACTUATED NEBULIZER ON AEROSOL DELIVERY.
Kai-Ying Liu1,2, Hui-Ling Lin1, Wen-Qie Liu1,2, Xin-Qiang Wang1; 1Department of Respiratory Care, Chang Gung University, Tao-Yuan, Taiwan; 2Respiraotry Therpay, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
Background: Breath actuated nebulizers (BAN) can increase inhaled mass in adults. Although manufacturer suggests that the (BAN) can be used for children with inspiratory flow rate higher than 15 L/min delivery efficiency with mask has not been reported. Objective: The purpose of this study is to demonstrate the influence of different pediatric aerosol masks used with a BAN during patient triggered, manually triggered and continuous aerosol output. Methods: A spontaneous pediatric lung model (ALS5000, IngMar Medical) with tidal volume 150 mL, inspiratory time 0.8 second, inspiratory flow rate 20 L/min, and respiratory rate 25 breath/min was attached to collecting filter and face form. The BAN (AeroEelipse, Monaghan Medical Inc) was tested with a standard pediatric aerosol mask (Galemed Cop), the Bubble of Fish aerosol mask (Pari Inc) and the valved aerosol mask for the BAN (Monaghan Medical Inc). The BAN was manually actuated (MA) during inspiration and continuous output (CON) with standard and Fish masks. The BAN breath actuated (BA) with the valved mask fit tightly on the model face. A unit-dose of 5.0 mg salbutamol (GSK Corp.) in 4 mL diluent was nebulized with 8 L/m of gas at 50-pisg (n=5). Inhaled drug was eluted from the filter and analyzed with a spectrophotometer (Hitachi Crop) at 276 nm. Mann-Whitney U test was used for statistical analysis, and p< 0.05 was used for statistical significance. Results: The figure illustrates the median % drug mass of unit-dose drug inhaled on the filter. With Breath actuation and valved mask, the BAN delivered up to 2 fold more drug than MA. CON delivered > 10 fold more inhaled drug than BA (p < 0.01). Conclusion: In this model of nebulization with a BAN to a spontaneously breathing pediatric patient, continuous output delivered more drug than either breath or manual actuation. Sponsored Research - None