2010 OPEN FORUM Abstracts
THE INFLUENCE OF PEDIATRIC AEROSOL MASK TYPES AND NEBULIZERS ON BRONCHODILATOR DELIVERY IN VITRO.
Wen-Qie Liu1,2, Hui-Ling Lin1, Xin-Qiang Wang1, Kai-Ying Liu1,2; 1Department of Respiratory Care, Chang Gung University, Tao-Yuan, Taiwan; 2Respiratory Therapy, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
Background: Breath enhanced nebulizer (BEN) has been reported to have higher efficiency than constant output nebulizers (CON). Previous studies showed that the Fish aerosol mask was more efficient than the standard aerosol mask. Objective: To compare the influence of pediatric aerosol masks when used with different types of nebulizers. Methods: Four nebulizers were compared with 2 masks. Three CONs including NebEasy (new design nebulizer to reduce dead volume), Neb-1 and Neb-2 (Galemed, Taiwan), were compared to the BE LC plus (PARI Inc.) using a standard aerosol mask (Galmed Corp) and Bubbles the Fish mask (Pari Inc.). A lung model (ALS 5000, IngMar Medical) simulated pediatric breathing parameters (Vt 150 mL, Tinsp 0.8 s, and RR 25 breath/min). Salbutamol (5mg in 4 mL NS) was nebulized with 8 L/m at 50-pisg. Inhaled drug was collected on a bacterial filter (Galemed) and eluted with distilled water, and analyzed by spectrophotometer (Hitachi Crop) at 276 nm. Mann-Whitney U test was used for statistical analysis, p< 0.05 used for statistical significance. Results: Table shows the median % (range) of total dose inhaled and dead volume. The Fish mask was more efficient than standard mask with CONs (p < 0.05) but not the BEN. The Neb-2 delivered more drug than other CONs or BE, with either mask (p < 0.05). . Conclusion: Mask and nebulizer selection can increase inhaled dose-up to two fold in this model of simulated pediatric ventilation. Sponsored Research - None