The Science Journal of the American Association for Respiratory Care

2010 OPEN FORUM Abstracts


Patricia A. Dailey, Kyle Walsh, Ploypan Thongpradit; Respiratory Care, Baystate Medical Center, Springfield, MA

INTRODUCTION; Vibrating mesh technology with drop by drop aerosol delivery has created a new paradigm in continuous aerosol delivery. Aerosol production occurs intermittently when solution is dropped on to the vibrating mesh with some pauses between aerosol. The pause varies based on the delivery rate of the solution. Our objective was to determine the pause time at varying rates and determine if they exceeded inhaled epoprostenol sodium’s minimum 6 minute half life. In addition we were curious whether the use of a tapered aerosol tip would shorten pause times. METHOD: A pulmonary infusion pump (CME America 575 BodyGuard) with a dedicated infusion set was used to deliver solution (nss) to a vibrating mesh nebulizer (Aerogen® ProX & Aeroneb Solo). We compared a control group, utilizing an exposed vibrating mesh surface without the medication cup, with the experiment group, Solo at varying flow rates of 1 ml, 2ml and 4 ml per hour. Droplets formed and were observed. The length of the aerosol was timed as well as the length of the pause. RESULTS: Mean pause times for control group at 1ml, 2ml and 4 ml were 226±34, 111±15, and 54±8 seconds. Mean pause times for experiment group at 1ml, 2ml and 4 ml were 276±75, 179±103, and 50±16 seconds. CONCLUSIONS: The term “continuous aerosol” can be confusing when associated with this new paradigm in inhaled medication delivery. We determined that it does not necessarily refer to continuous aerosol production but rather intermittent aerosol production at a set delivery rate, volume/time. In this model pause times for both groups were significantly less than 6 minutes, the half-life of epoprostenol sodium. Most inhaled medications have a half-life greater than 6 minutes and should not be affected by the pauses that were observed in this study. Sponsored Research - None