The Science Journal of the American Association for Respiratory Care

2010 OPEN FORUM Abstracts

THE INFLUENCE OF PEDIATRIC AEROSOL MASK TYPES AND NEBULIZERS ON BRONCHODILATOR DELIVERY IN VITRO.

Wen-Qie Liu1,2, Hui-Ling Lin1, Xin-Qiang Wang1, Kai-Ying Liu1,2; 1Department of Respiratory Care, Chang Gung University, Tao-Yuan, Taiwan; 2Respiratory Therapy, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan

Background: Breath enhanced nebulizer (BEN) has been reported to have higher efficiency than constant output nebulizers (CON). Previous studies showed that the Fish™ aerosol mask was more efficient than the standard aerosol mask. Objective: To compare the influence of pediatric aerosol masks when used with different types of nebulizers. Methods: Four nebulizers were compared with 2 masks. Three CONs including NebEasy (new design nebulizer to reduce dead volume), Neb-1 and Neb-2 (Galemed, Taiwan), were compared to the BE LC plus (PARI Inc.) using a standard aerosol mask (Galmed Corp) and “Bubbles the Fish” mask (Pari Inc.). A lung model (ALS 5000, IngMar Medical) simulated pediatric breathing parameters (Vt 150 mL, Tinsp 0.8 s, and RR 25 breath/min). Salbutamol (5mg in 4 mL NS) was nebulized with 8 L/m at 50-pisg. Inhaled drug was collected on a bacterial filter (Galemed) and eluted with distilled water, and analyzed by spectrophotometer (Hitachi Crop) at 276 nm. Mann-Whitney U test was used for statistical analysis, p< 0.05 used for statistical significance. Results: Table shows the median % (range) of total dose inhaled and dead volume. The Fish mask was more efficient than standard mask with CONs (p < 0.05) but not the BEN. The Neb-2 delivered more drug than other CONs or BE, with either mask (p < 0.05). . Conclusion: Mask and nebulizer selection can increase inhaled dose-up to two fold in this model of simulated pediatric ventilation. Sponsored Research - None