2010 OPEN FORUM Abstracts
EVALUATION OF SYSTEMIC CIRCUIT PARTICLE DEPOSITION USING THE AEROGEN MICROPUMP AEROSOL GENERATOR WITH A VARIABLE FLOW NCPAP SYSTEM.
Kimberly Farney1, Brandon Kuehne1, Laurie Gibson2; 1NICU, Nationwide Childrens Hospital, Columbus, OH; 2Department of Nuclear Medicine, Natinwide Childrens Hospital, Columbus, OH
Background Much debate has taken place regarding the efficacy of aerosolized medications given through nasal CPAP systems. The Aerogen micropump aerosol generator has traditionally been an acceptable method of aerosolized medication delivery in the hospital setting. However, little is known about how much drug is actually delivered to the patient when used inline with a variable flow nasal CPAP system. Methods We created a system that employed a test lung placed in a plastic jar. The jar was subjected to negative pressure by means of time/valve mechanism connected to a suction system. Simulated inspiration effort was measured by use of a heated wire anemometer. The flow signal was then integrated with an Avea ventilator. We used 3 ml of TC99mTC DTDA as our aerosol. The Aerogen was placed inline with a Cardinal Infant Flow Generator system connect to a CPAP driver. All nebulizer sessions were done over 15 minutes. The Aerogen was placed either proximally and distally in the circuit and patient effort was simulated at a 0.4L minute volume. All circuits were then placed under a GE Infinia Hawkeye Gamma Camera. Results Data was analyzed from 15 sessions. The Aerogen was placed at the heater,and the average medication delivery was 0.32%±.36(n=6). When the Aerogen was placed 18 inches from the prongs the average medication delivery was 21.41% ±11.49(n=9). Single factor analysis of variation (ANOVA) yielded a P= 0.0007 between the two placements. Conclusion This study suggests that the placement of the Aerogen, is associated with greater aerosolized medication delivery when the Aerogen is placed closer to the patient . As a result of this study a change of practice will occur regarding location of inline nebulizer placement. Sponsored Research - None