The Science Journal of the American Association for Respiratory Care

2010 OPEN FORUM Abstracts

A COMPARATIVE STUDY OF FVC, FEV1, AND TLC IN NON-SMOKING SAUDI STUDENTS AT EASTERN PROVINCE, SAUDI ARABIA WITH CAUCASIAN REFERENCE VALUES.

Noor Al-Khathlan1,2, Stephanie Enright2, Mohammed Amr EL-Noueam1; 1Respiratory Care Department, Dammam University, Dammam, Saudi Arabia; 2Department of Physiotherapy, Cardiff University, Cardiff, United Kingdom

Background: Pulmonary function tests (PFT) are the tests that used for detection and differentiation between restrictive and obstructive pulmonary diseases. It is well-known that the values of pulmonary function vary with age, sex, weight, body stature and the ethnic origin of the subjects (Cotes 1993; and Rupple 2009). Therefore, the American Thoracic Society (ATS) has recommended the development of population-specific lung function reference values (Rupple 2009). In the Kingdom of Saudi Arabia (KSA), the currently available reference values for pulmonary functions are mostly based on data from the Caucasian European population, which may be inaccurate for Saudi Arabian subjects as these populations differ markedly in their body characteristics and their environments. Therefore, this study seeks to investigate whether differences exists between adult Saudi’s FVC, FEV1 and TLC and Caucasians reference values for these parameters and to establish pulmonary function reference values specific for Saudi population. Method: This cross-sectional study was conducted at King Faisal University (KFU), Eastern Province, KSA, from June to August 2009. One hundred and twelve healthy non-smokers aged 18-22 years university students were participated in this study. A SensorMedics 6200 Body Plethysmograph (M Autobox, USA) was used to make all measurements for all subjects. Results: Statistically significant differences (p <0.01) were identified between the mean of the measured values of lung function for Saudis and the mean of Caucasian reference values. In regression analysis, height was found to be important independent variable for all pulmonary function parameters. Conclusions: In this study, the observed mean values for FVC, FEV1 and TLC for Saudis were found to be lower than the mean predicted values for Caucasian by about 10%; 5% and 8% for males respectively, and 16%; 12% and 5% for females respectively. This difference has led to the establishment of the first sets of prediction equations for Saudi population. A future larger study including all age, height and weight ranges from different regions in Saudi Arabia following the ATS criteria is needed. Sponsored Research - None Regression Equations derived from 112 healthy Saudi adults from the Eastern Province of Saudi Arabia (aged 18–22 years) Ht, Height in m; R2, coefficient of determination; RSD is the standard deviation of the residuals (residuals = observed - predicted) and the value of 1.64 * RSD corresponds to the prediction value at the lower fifth percentile. The lower limit of normal for each parameter can be calculated by subtracting 1.64 * RSD from the predicted mean