The Science Journal of the American Association for Respiratory Care

2011 OPEN FORUM Abstracts

EVALUATION OF CIRCUIT PARTICLE DEPOSITION USING THE AEROGEN MICROPUMP AEROSOL GENERATOR WITH A CLOSED-SYSTEM VENTILATOR CIRCUITS.

Kimberly Farney1, Jennah Hollen2, Brandon Kuehne1, Laurie A. Gibson3; 1NICU Respiratory Therapy, Nationwide Childrens Hospital, Columbus, OH; 2Respiratory Care, Nationwide Childrens Hospital, Columbus, OH; 3Department of Radiology, Nuclear Medicine Section, Nationwide Children's Hospital, Columbus, OH

Background There has been much discussion on the efficacy of aerosolized medication given through closed-system ventilator circuits. The Aerogen micro pump aerosol generator has traditionally been an acceptable method of aerosolized medication delivery system in the hospital setting. However, little is known about how much aerosolized medication is actually delivered to the patient when used in-line through closed-system ventilator circuit. Methods We performed testing through an Airlife Carefusion Infant Respiratory (RT4851-12) closed-system circuit connected to an Avea Ventilator utilizing a Bio-med device test lung. Each test disbursed a 3 ml of TC 99mTC DTDA as our aerosol. The Aerogen micro pump was placed either proximally or distally in the circuit and patient effort was simulated at a 0.45 minute volume. The two variables tested were an increased respiratory rate and placement of the Aerogen micro pump. All nebulizer sessions were performed over the duration of medication. All circuits were then placed under a GE Infinia Hawkeye Gamma Camera. Results Data was analyzed from 17 sessions. The Aerogen was placed at the heater, and the average medication delivery was 0 .20% ± 0.14 (n=6). When the Aerogen was placed 18 inches from the patient, the average medication delivery was 7.79% ± 4.2 (n=11). Single factor analysis of variation (ANOVA) yielded a P= 0.130 between the two placements Conclusion With the intubated patient there was not a statically difference in delivery of the aerosolized medication by increasing the minute volume. Additionally, we found that moving the Aerogen micropump closer to the patient resulted in no significant increase of medication delivery to the patient. Sponsored Research – None