2011 OPEN FORUM Abstracts
AEROSOL DEPOSITION USING A VIBRATING MESH NEBULIZER IN TWO POSITIONS DURING HIGH FREQUENCY OSCILATION IN AN INFANT LUNG MODEL.
Cathy Bardua, Rick Amato, James Johnson, Cynthia C. White; Respiratory Care Division, Cincinnati Children's Hospital Medical Center, Cincinnati OH
Background: Aerosol deposition to the lung remains controversial during High Frequency Ventilation (HFOV). Recent bench testing has been performed that evaluated deposition in several types of simulated adult lung models, but there is little data available that evaluates delivery in a simulated pediatric or infant setting. We conducted a filter study to evaluate lung deposition of albuterol during HFOV with a vibrating mesh nebulizer (VMN). Method: A VMN (Aeroneb, Solo,Aerogen) was placed inline with the 3100A HFOV (Viasys) at the patient wye for 2 testing conditions and prior to the humidifier for a third condition. An 8 french inline Ballard suction catheter with a wye adapter was connected to a 3.5 ETT measuring 18 cm in length and connected to a single chamber of an infant test lung (TTL, Michigan). Compliance was set at .003 ml/cmH20. Ventilator Settings: MAP 20, I time 33%, Power 2.24 (Amplitude 28), Flow 20LPM, FiO2 set at 60%. Hz was set at 10 and 12 for consecutive testing with the nebulizer positioned at the patient wye. Hz was set at 10 during testing of the VMN placed prior to the humidifier. The VMN was filled with a 3ml (2.5mg) dose of albuterol and nebulized continuously until empty. Albuterol was eluted from the filters and analyzed with the Nanodrop ND 1000 Spectrophotometer (276 nm). Results are reported in mm absorbance. Results: See chart. Discussion: In our simulated infant lung model, albuterol delivery with the VMN placed at the patient wye was similiar with settings of both 10 and 12 Hz. Minimal drug was absorbed in the filter when the nebulizer was placed prior to the humidifier. More testing needs to be conducted to compare nebulizer delivery during HFOV compared to other ventilation modalities in a simulated infant lung model. Sponsored Research None *mm absorbance