2011 OPEN FORUM Abstracts
ANALYSIS OF AEROGEN AERONEB SOLO NEBULIZER GAP TIME WITH AND WITHOUT THE AERONEB SOLO LEUR TO DETERMINE SAFE AND EFFECTIVE USE WITH FLOLAN.
Tiffany Pezzano; Thomas Jefferson University Hospital, Philadelphia, PA
Nebulized Flolan has an in vivo half-life of 3-6 minutes. Therefore, nebulization gaps inherent to the Aerogen nebulizer should not exceed 3 minutes for safe and effective use specific to aerosol interruption. This prompted us to carefully study gap times with and without the Solo Leur attached to the Aerogen nebulizer. Methods: We conducted a 2 hour bench test dripping normal saline into the Aerogen Aeroneb Solo nebulizer at 8 ml per hour via the Alaris pump. One hour was tested with the Solo Leur and one hour without it. We counted the aerosol gaps and timed their duration. Results: The Solo Leur produced 29 gaps in one hour with an average duration of 53.5 seconds (sd 25.7, median 58 seconds, high 94 seconds). Without the Solo Leur there were 21 gaps in one hour with an average duration of 96 seconds (sd 21, median 91 seconds, high 126 seconds). Conclusion: The Solo Leur inserted into the nebulizer had a greater number of gaps, less duration per gap and less total gap time per hour than without the Solo Leur in the nebulizer. However, neither the Aerogen nebulizer with or without the Solo Leur approached the 3-6 minute Flolan half-life range. This nebulizer can safely and effectively be used with Flolan because the gap durations are less than Flolan's half-life. Sponsored Research - None