2011 OPEN FORUM Abstracts
AN IN-VITRO COMPARISON OF THE BREATH ACTUATED NEBULIZER WITH THE JET NEBULIZER AT TWO DIFFERENT DRUG DOSAGES.
Abdullah S. ALQarni, James B. Fink, Robert Harwood, Arzu Ari; Respiratory Care, Gerogia State University, Atlanta, GA
BACKGROUND: Although previous studies compared breath actuated nebulizers (BAN) with jet nebulizers (JN), the efficiency of these nebulizers at different drug volume has not been reported. The purpose of this study was to compare the amount of drug deposition of the jet nebulizer (JN) with the breath-actuated nebulizer (BAN) using two different drug volumes. METHOD: The JN (Salter Labs) and BAN (AeroEclipse, Monoghan/Trudell Medical) were powered with oxygen at 8 L/min using an in-vitro lung model consisting of an adult teaching manikin upper airway connected to a breath simulator with a collecting filter (Respirgard II) at the level of the bronchi. Spontaneous breathing parameters were VT 450 mL, RR 20/min and I:E ratio 1:2. Albuterol dosages were 2.5 mg/3 mL and 2.5 mg/0.5 mL plus 0.5 mL normal saline (fill volumes of 3 mL and 1 mL, respectively). Drug eluted from filter with 0.1 HCl and analyzed with spectrophotometry (276 nm). Descriptive statistics and independent samples t-test were used for data analysis (p < 0.05). RESULTS: Table below shows mean +/- SD) of inhaled mass in mg of albuterol, % dose and time for both nebs and dose volumes. BAN delivers significantly more drug than JN at a fill volume of 3 mL (p=0.028) and 1 mL (p=0.004). Treatment time with BAN is significantly longer than JN at both fill volumes (p=0.0001 and p=0.013, respectively). Decreasing fill volume from 3 mL to 1 mL reduces inhaled mass by 45% with BAN and up to 64% with Salter, and treatment time is reduced by 90%, and 84%, respectively. CONCLUSION: Regardless of drug dosages used in this study, BAN is more efficient than JN. However, it was associated with longer treatment time. A reduction in fill volume decreases the amount of inhaled drug, and treatment time with both nebulizers. Sponsored Research - None