The Science Journal of the American Association for Respiratory Care

2011 OPEN FORUM Abstracts

RESISTANCE DETERMINATIONS OF A NOVEL AEROSOL DELIVERY ADAPTOR IN A NEONATAL MODEL.

Christopher Henderson1, Timothy J. Gregory1, Jan Mazela2, Russell G. Clayton1; 1Discovery Laboratories, Inc., Warrington, PA; 2Neonatology, Poznan University of Medical Sciences, Poznan, Poland

Backgound: Aerosolized medication delivery to the patient receiving ventilatory support is improved by optimizing placement of aerosol flow within the ventilator circuit. A novel technology has been developed to improve the delivery of aerosolized medications to neonates receiving ventilatory support. This technology includes a proprietary aerosol delivery adaptor designed to separate the aerosolized medication from ventilator bias flow, which in turn may result in improved aerosol medication delivery. Objective: To determine if the novel aerosol delivery adaptor increases respiratory system resistance in a ventilator circuit compared with a standard wye connector. Design/Methods: Utilizing various ventilator settings in a neonatal model, we assessed the resistive pressures of a standard patient wye connector (standard connector) and the novel adaptor. We assembled a neonatal testing system utilizing a Sechrist ventilator (Anaheim, CA), neonatal ventilator circuit, test lung, and Biopac MP150 (Goleta, CA). Testing was conducted on both the novel adaptor and a standard wye connector provided with the neonatal circuit. Testing was conducted at various ventilator settings with rates of 30 and 60 breaths/min, PEEP of 5 cmH2O, PIP of 15, 25 and 40 cmH2O. All test conditions were conducted in triplicate without and with a simulated aerosol flow rate of 7 L/min. To determine resistive pressure the following equation was used: R=P1->P2 (at a constant flow). Results: Table 1: Conclusion: The resistance was not different between the novel adaptor and the standard wye connector. Aerosolized medication delivery efficiency is also being assessed using the novel adaptor compared with current standard of care.
Sponsored Research - Discovery Labs, Inc.
Table 1