2011 OPEN FORUM Abstracts
EFFECT OF OMEPRAZOLE ON PULMONARY FUNCTIONS IN PATIENTS OF MILD TO MODERATE CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH GASTROESOPHAGEAL REFLUX.
Nitish L. Kamble1, Mradul K. Daga1, Naushad A. Khan2,1, Naresh Kumar1; 1Medicine, Maulana Azad Medical College, New Delhi, India; 2Biosciences, JamiaMillia Islamia, New Delhi, India
Background: Acid gastro-oesophageal reflux may aggravate respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD) by increasing airway hyperresponsiveness through vagally-mediated pathways we aimed to study the effect of omeprazole on Pulmonary functions in patients of chronic obstructive pulmonary disease with gastro esophageal reflux. Methods: The present study screened 38 mild and moderate COPD patients. All the patients underwent esophageal manometry and dual probe 24 hour esophageal pH monitoring. Twenty consecutive patients of diagnosed GERD received omeprazole 40 mg daily for 6 weeks. Spirometry was done at baseline and after 6 weeks of treatment. The primary outcome measures were improvement in reflux symptoms and the change in pulmonary function tests (FEV1, FEV1/FVC and PEFR) and blood oxygen saturation. Results: There was a significant reduction in GERD symptoms after therapy with omeprazole in comparison to baseline. Significant decline in FEV1 was observed after the therapy with a p value of 0.02. FEV1/FVC and PEFR compared with baseline and after therapy showed no improvement with p value of 0.056 and 0.31 respectively. A statistically significant improvement was seen in blood oxygen saturation after therapy with a p value of 0.04. Conclusion: Treatment with omeprazole in COPD patients with gastroesophageal reflux is beneficial by reducing the symptoms of GERD and improving the blood oxygen saturation. However it had no effect on pulmonary function. Abbreviations: COPD: Chronic obstructive pulmonary disease, GERD: Gastroesophageal reflux disease, FEV1: Forced expiratory volume in 1 sec., FVC: Forced Vital capacity, PEFR: Peak expiratory flow rate, SpO2 : Blood oxygen saturation Sponsored Research - None