The Science Journal of the American Association for Respiratory Care

2012 OPEN FORUM Abstracts


Wei-Ren Ke, Hui-Ling Lin; Respiratory Therapy Program, Chang Gung University, Taoyuan, Taiwan

Background: Aerosolized medication via small volume nebulizer (SVN) is most common used for treating respiratory symptoms in Taiwan. Due to the cost of these disposable SVNs, hospitals often reuse the SVN after pasteurization procedure for infection control between patients. Objective: The purpose of this study was to demonstrate the influence of reused-pasteurization procedure to the performance of SVNs. Methods: Twenty new SVNs (Galemed Cop) were test for comparison, and 18 pasteurized nebulizers were chosen randomly form respiratory care departments in Chang Gung Memorial Hospital. A spontaneous lung model (ALS5000, IngMar Medical) with tidal volume 600 mL, inspiratory time 1.0 second, and respiratory rate 12 breath/min was attached to collecting filter for inhaled mass collection. Particle size distribution were tested through an Anderson cascade impacter (Thermo Scientific). A unit-dose of 5.0 mg salbutamol (GSK Corp.) was nebulized with 8 L/m of gas at 50-pisg. Drug from the filter and collecting plates of the impactor was eluted and analyzed with a spectrophotometer (Thermo Fisher Scientific) at 276 nm. Independent t- test was used for statistical analysis, and p< 0.05 was used for statistical significance. Results: The table shows the mean inhaled drug (expressed as % of an unit-doseĀ±SD), mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD), and nebulization time. No statistical difference was found between new and pasteurized nebulizers. Conclusion: The performance of reused nebulizer under various times of pasteurization were similar. Further study needs be done to exam the limit for times of pasteurization procedure for nebulizer disinfection. Sponsored Research - None Comparison of nebulizersĀ’ performance