2012 OPEN FORUM Abstracts
A COMPARISON OF AEROSOL DRUG DELIVERY AND PLACEMENT WITH AND WITHOUT THE NEOFLOW SENSOR.
Lisa Tyler1, Leane Soorkian1, Linda Napoli1, James Fink2; 1Respiratory Care, The Childrens Hospital of Philadelphia, Philadelphia, PA; 2Respiratory Therapy, Georgia State University, Atlanta, GA
Background: Delivery of bronchodilators via Aeroneb is common in neonatal mechanically ventilated patients. Using a Dräger ventilator, Neoflow sensor placement at the airway is preferred, but impact on aerosol delivery with the sensor in-line has not been reported. Removal of the Neoflow sensor to deliver Albuterol to this patient population may lead to increased risk of Ventilator Associated Pneumonia and safety risks related to ventilator setting augmentations. Method: Dräger Evita XL set in PC 20/5 x 30 x 21%, 2.5 mg of albuterol was delivered via Aeroneb Solo placed distal (pre-humidifer) delivered through the inspiratory limb of a neonatal heated wire circuit (37 ± 1° C) with and without the Neoflow sensor. Drug was collected on a nonconductive respiratory filter distal to a 3.5 mm ETT, and attached to a passive test lung. The same circuit was used for all trials (n=3); they were performed in the order listed. Samples were eluted from the filters using an ethanol/water mixture. Absorbance at 276 nm was used to estimate the amount of albuterol in the eluent. Results: Table belowshows results of each run with ug of albuterol also expressed as mean ± SD. Conclusion: Despite a trend toward higher drug delivery with Neoflow removed, T test showed no statistical difference in the deposition with the Neoflow sensor present or absent from the circuit. Further studies are needed to standardize delivery method and quantify dose delivered with and without Neoflow. Sponsored Research - None Comparison of Drug Delivery With and Without Neoflow
